I have a P2S and it mostly works, and WITH the screen, in Mach4. Here is my humble assessment. Lee Neuman of VistaCNC needs to write a new plugin that works. He promised one an August, last August. So.....I would remove all plugins you don't use. Remove, not disable. I think the keyboard plugin is where the conflict is but I'm not the expert. If you don't use the Mach4 keyboard plugin, remove it. One thing I know is, in my case, I can't edit keyboard shortcuts with the Vista plugin even in the folder.. Remove it, edit keyboard shortcuts, put it back, keyboard shortcuts stick and the pendant works. Hence my theory on the keyboard plugin conflicting.
Other than that, we're waiting for Lee!
Tom