Yes, if you have home switches.
In Config > Homing Limits, you can enter a "Home Offset", which is the coordinates of the home switches. By adjusting the Home Offsets, you can get your 0,0 position exactly where you want it.
Then make sure you're G54 X and Y offsets are set to zero.
Now, when you home, your 0,0 position will always be in the same place. Your Origin in V Carve Pro will then correspond to the 0,0 position which is relative to your home switches.
Make sure that you never click the Zero X or Zero Y buttons, as they will move your 0,0 position.