SURE the CAM can handle it in the post with no problem.
SHEETCAM would work great for this as it is very capable in 2d work like punchpressing, plasma,laser,etc.
Just put drill points at the punch locations and let SC add a drill cycle at each point AND then MOD the post to output the M25 instead of the G81 drill cycle.
Les over at SC is great at supporting his users by helping with posts mods.
THEN it is very simple to convert a standard Cad drawing to a punch file(;-)
SheetCam, Never go to work without it. (;-)