You could have a lack of power and are losing steps.
Take off one of the motors keep the coupling on the shaft and set it to say vertical, Zero the DRO run it backwards and forwards it should always come back to the to the same position on the shaft when the DRO reads Zero.
Do this at a modest speed increasing the speed a bit at a time until you are doing it at maximum speed
If yes then you are losing steps when it is mounted to the machine if no then get back to try something else
Phil