I think if you look at the offset page on Mill - I take it that is what you are using - then (although I haven't used it myself) it seems that the settings you put in on this page are transferred to the active work offset - G54 to G59.
Do you then need to select this work offset to bring these into play
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Try (on the offsets page) selecting say G57, setting your offsets, then before you press cycle start, type in manually " G57 ". I would think it is set up this way so that you can put in several offsets for a program all at once, and select them as you need them.
If you try setting up some offsets on this page, then check with the fixtures table under "Config" you will see they are transferred.