Greg,
...................It appears to me that the primary reason for isolation is the chance of
inadvertent mistakes when making the connections.
After the connections are properly made, does the isolation offer any benefits ?
All I read about is fried ports being expensive to repair...especially on laptops.
Thanks for the help.
I'm not interested in participating in a debate about connection methods but as you asked me a question I will not be rude and ignore it....

"After the connections are properly made, does the isolation offer any benefits ?"
I can't think of any. Over the life of a machine faults may develop. It might help here.
More likely I think with a self built machine you will at some time start making alterations to incorporate some new beaut feature. Maybe then it might help.

"All I read about is fried ports being expensive to repair.........."
I've been following this forum among others for a while now.
About once a week I read about someone who has fried drivers, power supply or some other component.
Can't remember a report of a fried printer port. I'm sure it happens. I don't think it happens very often.
I use a PCI printer port. Costs about $20. Probably the cheapest component in my control setup. I don't lose sleep about it.

".........especially on laptops."
I certainly would not use a new expensive laptop in my shed. Dusty very anti laptop environment.
However I have used an old laptop that has been retired from daily use. Not worth much.

Greg