Hi,
no, a Mach3 Brain cannot be used in Mach4.
Mach4 has both a PLC, a superfast equivalent to a Mach3 Macro Pump, and PMC, a Lua equivalent of a Mach3 Brain, ie
ladder logic. Aside from those two features in Mach4 you can craft your own M3, M4's etc, so you may find that you
don' need any of the extra frilly stuff.
Craig