Help - Mill not starting anymore.

Mach3 will successfully Load G-Code and Cycle Start. G-Code runs in Mach3 with no issue.

However my mill does not respond anymore. I am not sure what has changed.

Everything is powered on and all cables are secure and appear undamaged.

What troubleshooting steps should I consider next?

I have noticed under my Ports & Pins in the Input Signals and Output Signals tabs that every has a red X now.

I think this may be why my mill is not receiving output from Mach3.

Trying to figure out now how Input Signals and Output Signals should be reconfigured.