It sounds like something that happened to me a while back. You press one of the jog buttons and it locks up some other buttons?
Mine was because I didn't have a motion device selected; kind of weird because the SIM should allow jogging on screen jogging, but, that's what it was.
Another time it was because somehow my motors were turned off and it locked stuff up; this has been over a year now, but that's what happened to me before.