Yes
I have a dell optiplex as my mill controller with all the unused bits removed eg cortana,update functions , and ssd sleep disabled , infact all energy saving sleep functions are disabled , though Gpedit as it a 64bit pro w10 , yes I think I am correct that Mach 4 is a single thread 32bit program ,but I will stand corrected on that.
Now my take on 16gb af ram
I had 8gb installed it was sluggish on startup and load times increasing the ram to 16gb reduced the boot time by half mach4 loads in 4 secs that includes getting the Ethernet SS up and running .
I did notice I was getting some page outs at 8 but not at 16
But note that’s all the dell does is control the mill ,
I use a iMac for the CAD/CAM stuff and that’s in the house , but note I am a hobbiest and do not earn my living from my workshop