Depends on what you're looking for, 2.5D or 3D.
For the 2.5D I'd look closely at D2nc. I have it and absolutely love it.
Others will find other software easier.
The main thing to understand is there will be some sort of learning curve with any of them. Stick to the one that appeals to you and dig in and learn it.
There are many demo versions available for various ones.
Probably not the answer you were looking for, but there's no sense in starting a war here with who's got the best.