There is more to CNC machining than just plug in the machine and play. So loading a file without reading the manual to see it run is
like being blind folded and deciding to take a trip down the race track in a car and hope you get to the end.
There are machine, part, program coordinates and there are machines with, without limit switches and also soft limit switches. Then you also have offsets, tool compensation , and a number of other things to consider, etc. You configure Mach according to the machine and how you are going to work.
You also set up the machine before running a program.
Now also understand that depending on how a part is defined in say CAD, then the CAM, then processed, and how Mach is configured all have an affect on what the axis movements are relative to the piece.
That all said, we'll keep it super simple .............for no tool offsets, no switches, no soft limits, siingle piece to be done, etc........
Wherever 0,0,0 (origin) is in the programs code that is where you want to set the tool, so you just move to that point and once the cutter is set at the
location, you simply click ref all home button and now the XYZ Dro's will be 0. So machine, program, part and tool are all set to the same spot.
Hopefully your piece is positioned on the table such that any axis travels are within the table travels.
What happens after starting the program depends on what instructions the code gives to Mach. Dry run the program with no tool and clear of the material to be assured all is well.
RICH