I don't use LazyCAM, but a lot of simple CAM programs like it will start the cutting where the start of the line is in thew .dxf file.
Yes, your origin (0,0) is the upper right, but most likely, the square in the .dxf is draw starting at the lower left corner. Better CAM programs will allow you to set the start point. Or you can try to make sure when you draw it in your CAM program, you draw it exactly the way you want it to cut.