Thank you HimyKabibble for the answer.
The PC is a Pentium 4 / 3GHz, 1 G RAM, I don't think this is the problem.
I run on it without any problem MACH2.
I tryed Making the .XML read-only, it didn't solved the problem. Now it happened at 5000 lines.
Probably the program loads it at the start, and after that it can change it.
It is not "a crack version" Manmardam.
I just downloaded it from artofcnc.ca version 3.042.029, with the old licence that I used with MACH2