I need a switch to execute a macro.  I cannot just use a brain because the macro turns off one output and turns on another. And there is conflict if there is a mcode and brain turning on/off the same port and pin. Seems like there should be an easy way to do this. I wish i could just put the mcodes in the brain.

Check out OEMTriggers

Looks like OEMTriggers can not be edited. You can only select from a list.

I made an onscreen button to open and close the collet via macro. Is there a way to assign it a number and be able to execute from brain or pokeys?

If you save the script in the Macros folder with a name like M1003.m1s then you can call it from a button script with these two lines:-

Filepath = "C:\Mach3\macros\Mach3Mill\M1003.m1s"
RunScript(Filepath)

Or from MDI or in a program.