Funny thing is its only if I activate port2.
What could cause this?

Not enough info to even hazard a guess.

adress issue? printerport on motherboard running X-Y-Z runs perfectly as long as port2 is not active, no pins are assigned in port2.
additional printerport on PCI with adress 0xe00 react to inputs when I assign pins but for some reason interferes with the outputs on port1.
x-y reacts just as if the I-J-K issue ,cropcircles,

Crop circles could be the IJ mode setting in general config, this can also be set in your CAD/CAM output.

Do you need 2 LPT ports?

What version of Windows are you running?

What settings do you have in Port#1 and Port#2?

Problem solved.

I just uninstalled and installed again,
 same adress as before.