hIo, rc = mc.mcIoGetHandle(inst, "Sim0/Input0")
ioinf, rc = mc.mcIoGetInfoStruct( hIo)
rc = mc.mcIoSetDesc(hIo, "Input0 test desc")

-- this code not saving changes to profile

rc = mc.mcProfileFlush(inst)
rc = mc.mcProfileSave(inst)

-- and this code not help