You could use a setting jig something like the picture.
Make the jig from 1/4" alum plate and bolt it to the machine table anywhere, then clock it square to the axis.
The 1/2" hole is a setting hole so you can clock it at the start and set X and Y zero at this point.
Then have G54 set at -12" and -6"
The 3 off 1/4" dia pins then locate the work in the correct place.
The drawing is in metric by the way.
Graham.