Hello,
It sounds like the polarity of your direction pin for your X axis needs to be reversed. You can do this in the PMDX plugin configuration. This is a common adjustment to make when configuring a new profile. If your Y axis moves in a positive direction away from you, you want your X to move in a positive direction to the left. However, if your Y axis moves in a positive direction towards you, your X would need to move in a positive direction towards the left to be following right-hand rule. Right-hand rule dictates movement of the axes in relation to each other, but your machine itself can be oriented however you want it to be. I hope that makes sense and helps you. Please feel free to send me a PM here or submit a ticket at support.machsupport.com if you need any additional support.
Best wishes,
Bryanna