I don't know if this is only happening to me. I run Mach4 as admin and configure the ShuttlePro buttons. All works well for the current session but when I restart Mach4 all the setting I made is gone.

Is there a solution for this?

I have the same problem and haven't been able to find any useful help on the MachSupport.com/forum. I'm running Mach4 in Win 10 Home on an ASUS X550Z laptop.

I know nothing about ShuttlePro's, but I DO know my VistaCNC pendant will NOT save it's settings if the Mach4 keyboard plugin is active. I disabled/removed the keyboard plugin, restart Mach and maybe even the PC, setup the VistaCNC pendant, restart again to save settings, re-enabled the Mach keyboard plugin, after a restart, all is good. Might be worth a try. Seems to me there are conflicts with the Mach keyboard plugin and other plugins that seem to "use" the keyboard:)