Having owned and operated several co2 machines and one galvo fiber laser I can speak from some background. Not sure of what power your talking about and material. But my 40 or 50 watt machines can cut .250 or 6 mm plywood without an issues, cedar wood or pine same thickness it does a better job. The glue in the plywood is sometimes an issue. Anodized aluminum engraves without issues. Dust or smoke removable via exhaust fans to outside. At one time I looked into building one, but its cheaper just to purchase a pre-built Chinese and fix as needed.

. The more expensive US and German machines use a air cooled RF metal tube.
Tube (glass) is fixed at one place, water cooled usually in the Chinese ones. Mirrors direct the beam, the moving carriage has the last mirror and it reflects down thru the lens to focus the dot. The really larger machines, as the Kern has the tube mounted so it moves with the gantry.
If you want to engrave, Mach3 is not the way to go, cutting yes. The DSP controllers do a great job for engraving and cutting.