Hi Michael,
how are you, last time we talked was at the manufacturing show.
I don't specifically know the answer to your question but I've never had that problem after leaving my machine just "sitting there" for some time.
All I can say is a go absolutely crazy with disabling anything I can possibly think of, that is not necessary for Mach3. Anything to do with power saving, screen power down, screen savers. I go through all Windows services and disable anything I THINK is not needed. I un-install any built in XP applications like Internet Explorer, etc
I even look in the BIOS and see if there's anything I can disable there, like networking, sound, etc.
When installing XP I go through the XP optimisation guide for Mach3 and install in "Standard PC" mode.
After all that if I don't get a fantastic driver test without glitches, or if I have any other issues, I try a different PC. I've found some PCs just don't work as good with Mach3.
Keith.