Mick1969,
Don't play with your mouse even if USB connected. Same reason as reply #1.
sebashtionh,
Some folks have no problems with a wireless mouse. I have had problems with a wireless at times depending on what I was doing.
Never a problem with direct connected. Reply #2 is just one example of what can happen, ie; something can interfere with the mouse receiver.
I don't play with my mouse as others do when running a program! Leave it alone. Same can happen with a wireless keyboard.
Remember that you are running a machine and want as solid as possible a connection to control it.
Just my opinion,
RICH