At my day job, we have a large Morbidelli, that has a dust collection "manifold" with pneumatic valves to direct the vacuum to the required zones. One to the router, one to the drilling head, and one to the rake that unloads the table and cleans it at the same time.
I've thought about doing the same thing with mine, one for each spindle. I'll probably be using a 5" hose to the manifold, running from a Harbor Freight 2HP dust collector.