I run a Mac Pro as my primary machine, I dual boot with WinXP. I do part design and programming in XP, but everything else in OSX. Helps to keep Windows clean and working well. That being said if you were to use something like Parallels Desktop or VMware with a copy of Windows I don't see why you couldn't get a driverless install with no machine connected to run fine. I have never personally tried this mind you, I have my doubts about the ability of my graphics card to do Solidworks well in a virtual machine, so I've not bought Parallels. If I do wind up trying it I'll post my results on how the machine does.