Finally I fix the problem. I think. 
After many electronics test I found the problem, which was the Optocoupler IC from step motors drivers.
After I changed all optocouplers from drivers the problem disappeared. 
Great! Now my CNC is running fine and accurate.
I think that one signal probable "DIR" was retarded by the old optocoupler then the step motor driver loses "step pulses". 
I don't have a scope and I think that with one , this kind of problem would be more easily set on.
Thanks Jim
Thanks All.
Nemoc