Hi Just an update.
Embarassingly, it seems to have been a wiring or switch fault on the e-stop. Arturo suggested I just use a short wire link on the board estop terminals to eliminate any potential wiring issues. The problem cleared immediately.
Strange though, I thought I had done the same a couple of days ago before posting on here.
Still nothing moving but at least the board seems to be responding. I can hopefully work through the rest over the next few days.
Thanks very much for the help & advice.
Paul