I am running a 9x49 bridgeport clone with no problem as well as my most recent conversion a 30 hp lathe . The software isnt the limiting factor on machine size and speed , its a matter of choosing the proper drives and motors for your application. AutomationDirect as well as yaskawa, mitsubishi, allen bradley etc have ac servo motors and drives cabaple of positioning any load you can imagine
I have used quite a few of the commonly avail software packages , break out boards and drives over the past ten years and Mach is by far the easiest to configure with all the bells and whistles to match any possible configuration.
The only thing missing I would like is a qaudreture encoder input for rigid tapping and spindle indexing on the mill, Would also be nice to be able to use the live tooling on my new lathe also
For my 30hp lathe I used the 2kw brushless ac servos and matching drives from automation direct and am able to move the saddle/cross-slide/ tool changer assembly at 800IPM , over 600lb assembly.
The support avail is also above and beyond , Hood has gone way far out of his way to answer all my questons no matter how stupid and has helped me get the 12 station tool changer running. You wont find a better group of guys to help you out when a question arises.