Sure can, you could create a custom macro and call it from your g code or add it to the init string in general config. Just open the script editor, write you macro and save as M3333.m1s for example. then add the M3333 to your gcode files. All the macro would need would be SetOEMDRO(*,100) Replace the star with the dro number for spindle percentage........... can't remember the number.
Brett