Check the Target properties of your desktop shortcuts,
If the profile for /p Mach3Turn works and /p dans_cnc does not work then, in the Mach3 folder, delete dans_cnc.xml (make a backup first) and rename Mach3Turn.xml to dans_cnc.xml
Then, to correct the screen, in menu View / Load Screens select 1024.set to recover the Mach3 Mill screen. Close then restart Mach3.
Tweakie.