If your PC will install 5 ports (only ever had 2 before) then no need to disable anything. Just have the two
profiles for your machines and have the appropriate port address for whichever machine is connected to these ports. Start the Mach profile you want and all should be well.
Hood
That's what I was a little confused about, because a PC will only recognise 3 LPT ports connected to it at any one time and I wanted to disable the motherboard port when running CNC stuff.