You DO mean right clicking the Mach shortcut, Properties, Compatibility, and setting Run as Administrator?
It all depends on how you have UAC (User Access Control) configured. If you have it turned off then you will likely not have an issue. I have UAC on and my Mach link set to Run As Administrator so I get a pop-up window asking me if I want to allow it to maker changes to my computer each time I launch it. (Kind of annoying but not a big deal, it is a very good safety net against various viruses, etc.) The best thing to do if one is in doubt is to 'Run As Administrator'.